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(Reuters) - Amazon.com Inc said on Thursday it would buy small online pharmacy PillPack, a move that will put the world’s biggest retailer in direct competition with drugstore chains, drug distributors and pharmacy benefit managers.

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FILE PHOTO: An Amazon.com Inc driver stands next to an Amazon delivery truck in Los Angeles, California, U.S., May 21, 2016. REUTERS/Lucy Nicholson/File Photo

The potential of Amazon’s (AMZN.O) move to disrupt major players across the drug supply chain on a nationwide level prompted a selloff in shares of potential future rivals, while sending its own shares up 2 percent.

PillPack supplies pre-sorted prescription drugs and other services for people who take multiple medications, a growing market as the U.S. population ages and requires treatment for multiple complex, chronic conditions.

The value of the deal was not disclosed. Bloomberg reported it to be $1 billion, citing a person it said was familiar with the matter.

The announcement cost drug store and medical wholesaler investors around $19 billion in stock losses on Thursday, while Amazon gained about $5.2 billion in value.

Shares of CVS Health (CVS.N) were down nearly 8 percent, while Walgreen Boots Alliance (WBA.O) fell 10 percent. Shares of drug wholesalers McKesson Corp (MCK.N), Cardinal Health (CAH.N) and AmerisourceBergen (ABC.N) also fell sharply.

The news comes just a week after a joint venture of Amazon, Berkshire Hathaway Inc (BRKa.N) and JPMorgan Chase & Co (JPM.N) named a CEO who will be tasked with significantly cutting healthcare costs.

Although brick-and-mortar stores might feel the effects of Amazon’s competition, the biggest battles will likely be fought by the mail-order pharmacies, which generally serve patients with chronic conditions such as heart disease that

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